There's also a long thread about this issue on the spamassassin mailinglist here:
http://lists.centos.org/pipermail/cento ... 21652.html
The final fix for a couple of people seems to be downgrading perl-NetAddr-IP from the RepoForge version to the package from the vendor.
I see the problem on servers that don't use RepoForge and have the stock EL5 perl-NetAddr-IP package installed. Maybe the combination of this package and the perl-IO-Socket-INET6 from Atomicorp doesn't work too well?
spamassassin-3.3.2-7.el5.art.x86_64
perl-IO-Socket-INET6-2.67-1.el5.art.noarch
perl-Net-DNS-0.59-3.el5.x86_64
perl-NetAddr-IP-4.027-5.el5_6.x86_64
The error occurs when the SpamAssassin daemon is restarted, not when sa-update is running like the thread's subject suggest. (But the SpamAssassin daemon is restarted after sa-update installs updated rules.)