PHP Fatal error: [ionCube Loader] The Loader must appear in the php.ini file before other extensions in Unknown on line 0
Failed loading /usr/lib/php4/ioncube_loader_lin_4.4.so: /usr/lib/php4/ioncube_loader_lin_4.4.so: cannot open shared object file: No such file or directory
I use Ioncube w/ PHP 4.4.2 and it works fine. When I installed the Plesk 8 updates I had an issue similar to yours but I just needed to adjust the order the extensions were loaded in.